Divergence across mitochondrial genomes of sympatric members of the Schistosoma indicum group and clues into the evolution of Schistosoma spindale

Jones, Ben P., Norman, Billie F., Borrett, Hannah E., Attwood, Stephen W., Mondal, Mohammed M. H., Walker, Anthony J., Webster, Joanne P., Rajapakse, R.P.V. Jayanthe and Lawton, Scott P. (2020) Divergence across mitochondrial genomes of sympatric members of the Schistosoma indicum group and clues into the evolution of Schistosoma spindale. Scientific Reports, 10, p. 2480. ISSN (online) 2045-2322

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Abstract

Schistosoma spindale and Schistosoma indicum are ruminant-infecting trematodes of the Schistosoma indicum group that are widespread across Southeast Asia. Though neglected, these parasites can cause major pathology and mortality to livestock leading to significant welfare and socio-economic issues, predominantly amongst poor subsistence farmers and their families. Here we used mitogenomic analysis to determine the relationships between these two sympatric species of schistosome and to characterise S. spindale diversity in order to identify possible cryptic speciation. The mitochondrial genomes of S. spindale and S. indicum were assembled and genetic analyses revealed high levels of diversity within the S. indicum group. Evidence of functional changes in mitochondrial genes indicated adaptation to environmental change associated with speciation events in S. spindale around 2.5 million years ago. We discuss our results in terms of their theoretical and applied implications.

Item Type: Article
Research Area: Agriculture, veterinary and food science
Allied health professions and studies
Biological sciences
Epidemiology and public health
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing
Faculty of Science, Engineering and Computing > School of Life Sciences, Pharmacy and Chemistry
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Depositing User: Scott Lawton
Date Deposited: 20 Feb 2020 14:44
Last Modified: 24 Mar 2020 16:22
URI: http://eprints.kingston.ac.uk/id/eprint/45005

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