Associations with photoreceptor thickness measures in the UK Biobank

Chua, Sharon Y. L., Dhillon, Baljean, Aslam, Tariq, Balaskas, Konstantinos, Yang, Qi, Keane, Pearse A., Tufail, Adnan, Reisman, Charles, Foster, Paul J., Patel, Praveen J., UK Biobank Eye and Vision Consortium, ..., Barman, Sarah A., ... and Tapp, Robyn (2019) Associations with photoreceptor thickness measures in the UK Biobank. Scientific Reports, 9, p. 19440. ISSN (online) 2045-2322

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Abstract

Spectral-domain OCT (SD-OCT) provides high resolution images enabling identification of individual retinal layers. We included 32,923 participants aged 40–69 years old from UK Biobank. Questionnaires, physical examination, and eye examination including SD-OCT imaging were performed. SD OCT measured photoreceptor layer thickness includes photoreceptor layer thickness: inner nuclear layer-retinal pigment epithelium (INL-RPE) and the specific sublayers of the photoreceptor: inner nuclear layer-external limiting membrane (INL-ELM); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (ISOS-RPE). In multivariate regression models, the total average INL-RPE was observed to be thinner in older aged, females, Black ethnicity, smokers, participants with higher systolic blood pressure, more negative refractive error, lower IOPcc and lower corneal hysteresis. The overall INL-ELM, ELM-ISOS and ISOS-RPE thickness was significantly associated with sex and race. Total average of INL-ELM thickness was additionally associated with age and refractive error, while ELM-ISOS was additionally associated with age, smoking status, SBP and refractive error; and ISOS-RPE was additionally associated with smoking status, IOPcc and corneal hysteresis. Hence, we found novel associations of ethnicity, smoking, systolic blood pressure, refraction, IOPcc and corneal hysteresis with photoreceptor thickness.

Item Type: Article
Additional Information: This work was supported by the National Institute for Health Research [Biomedical Research Centre and Clinician Scientist award (CS-2014-14-023)], UCL Institute of Ophthalmology, University College London, Eranda Foundation via International Glaucoma Association and the Richard Desmond Charitable Trust via Fight for Sight UK.
Research Area: Other laboratory based clinical subjects
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing
Depositing User: Philip Keates
Date Deposited: 15 Jan 2020 13:38
Last Modified: 15 Jan 2020 13:38
DOI: https://doi.org/10.1038/s41598-019-55484-1
URI: http://eprints.kingston.ac.uk/id/eprint/44830

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