The growing threat of gonococcal blindness

Dolange, Victoria, Churchward, Colin P., Christodoulides, Myron and Snyder, Lori A. S. (2018) The growing threat of gonococcal blindness. Antibiotics, 7(3), p. 59. ISSN (online) 2079-6382

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Abstract

Antibiotic-resistant gonorrhea is now a reality, as well as the consequences of untreatable infections. Gonococcal eye infections result in blindness if not properly treated; they accounted for the vast majority of infections in children in homes for the blind in the pre-antibiotic era. Neisseria gonorrhoeae infects the eyes of infants born to mothers with gonorrhea and can also infect the eyes of adults. Changes in sexual practices may account for the rise in adult gonococcal eye infections, although some cases seem to have occurred with no associated genital infection. As gonorrhea becomes increasingly difficult to treat, the consequences for the treatment of gonococcal blindness must be considered as well. Monocaprin was shown to be effective in rapidly killing N. gonorrhoeae, and is non-irritating in ocular models. Repeated passage in sub-lethal monocaprin induces neither resistance in gonococci nor genomic mutations that are suggestive of resistance. Here, we show that 1mMmonocaprin kills 100% of N. gonorrhoeae in 2 min, and is equally effective against N. meningitidis, a rare cause of ophthalmia neonatorum that is potentially lethal. Monocaprin at 1mMalso completely kills Staphylococcus aureus after 60 min, and 25 mM kills 80% of Pseudomonas aeruginosa after 360 min. Previously, 1 mM monocaprin was shown to eliminate Chlamydia trachomatis in 5 min. Monocaprin is, therefore, a promising active ingredient in the treatment and prophylaxis of keratitis, especially considering the growing threat of gonococcal blindness due to antimicrobial resistance.

Item Type: Article
Uncontrolled Keywords: gonococcal blindness, antimicrobial resistance, ophthalmia neonatorum, monocaprin, 34 Neisseria gonorrhoeae, Neisseria meningitidis, gonococci, meningococci
Research Area: Biological sciences
Chemistry
Infection and immunology
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing > School of Life Sciences, Pharmacy and Chemistry
Depositing User: Katrina Clifford
Date Deposited: 03 Aug 2018 10:14
Last Modified: 13 Aug 2018 12:27
DOI: https://doi.org/10.3390/antibiotics7030059
URI: http://eprints.kingston.ac.uk/id/eprint/41377

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