Stability-indicating method for the determination of Rivaroxaban and its degradation products using LC-MS and TLC

Arous, Basima, Al-Mardini, Mohammad Amer, Ghazal, Heba and Al-Lahham, Fida (2018) Stability-indicating method for the determination of Rivaroxaban and its degradation products using LC-MS and TLC. Research Journal of Pharmacy and Technology, 11(1), pp. 212-220. ISSN (print) 0974-3618

Full text available as:
[img]
Preview
Text
Ghazal-H-40881-AAM.pdf - Accepted Version

Download (796kB) | Preview

Abstract

A validated stability indicating thin layer chromatographic (TLC) and liquid chromatography coupled with mass spectrometry LC/MS methods were developed to analyse Rivaroxaban and its degradation products. Forced degradation studies under stress conditions were carried out in order to establish its stability profile. Stress conditions recommended by the International Conference on Harmonization (ICH) including oxidative, photolytic, thermal, acidic, and basic hydrolysis were applied. Rivaroxaban found susceptible to acid and base hydrolytic stress conditions. Degradation products were identified isolated and characterized using LC-MS and TLC. Three major degradation products were detected, separated and determined and two of them were further characterized by NMR spectroscopy and FT-IR.

Item Type: Article
Research Area: Pharmacy
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing (until 2017) > School of Pharmacy and Chemistry
Related URLs:
Depositing User: Heba Ghazal
Date Deposited: 04 Apr 2018 09:01
Last Modified: 10 Apr 2018 10:13
DOI: https://doi.org/10.5958/0974-360X.2018.00040.9
URI: http://eprints.kingston.ac.uk/id/eprint/40881

Actions (Repository Editors)

Item Control Page Item Control Page