Multiple measures of adiposity are associated with mean leukocyte telomere length in the Northern Finland Birth Cohort 1966

Buxton, Jessica L., Das, Shikta, Rodriguez, Alina, Kaakinen, Marika, Couto Alves, Alexessander, Sebert, Sylvain, Millwood, Iona Y., Laitinen, Jaana, O'Reilly, Paul F., Jarvelin, Marjo-Riitta and Blakemore, Alexandra I. F. (2014) Multiple measures of adiposity are associated with mean leukocyte telomere length in the Northern Finland Birth Cohort 1966. PLoS ONE, 9(6), e99133. ISSN (online) 1932-6203

Full text available as:
[img]
Preview
Text
Buxton-J-40223-VoR.PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview

Abstract

Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere length throughout life remains unclear. We therefore tested association of adult LTL measured in 5,598 participants with: i) childhood growth measures (BMI and age at adiposity rebound (AR)); ii) change in BMI from childhood to adulthood and iii) adult BMI, waist-to-hip ratio (WHR), body adiposity index (BAI). Childhood BMI at AR was positively associated with LTL at 31 years in women (P = 0.041). Adult BMI and WHR in both men (P = 0.025 and P = 0.049, respectively) and women (P = 0.029 and P = 0.008, respectively), and BAI in women (P = 0.021) were inversely associated with LTL at 31 years. An increase in standardised BMI between early childhood and adulthood was associated with shorter adult LTL in women (P = 0.008). We show that LTL is inversely associated with multiple measures of adiposity in both men and women. Additionally, BMI increase in women from childhood to adulthood is associated with shorter telomeres at age 31, potentially indicating accelerated biological ageing.

Item Type: Article
Additional Information: This work was supported by the Wellcome Trust [grant number: WT088431MA], Medical Research Council [grant number: G0500539], National Institute for Health Research and Imperial College Health Care NHS Trust.
Research Area: Biological sciences
Epidemiology and public health
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing (until 2017) > School of Life Sciences
Related URLs:
Depositing User: Jessica Buxton
Date Deposited: 11 Dec 2017 10:36
Last Modified: 11 Dec 2017 14:13
DOI: https://doi.org/10.1371/journal.pone.0099133
URI: http://eprints.kingston.ac.uk/id/eprint/40223

Actions (Repository Editors)

Item Control Page Item Control Page