Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration

Athanasiou, Dimitra, Aguila, Monica, Opefi, Chikwado A., South, Kieron, Bellingham, James, Bevilacqua, Dalila, Munro, Peter M., Kanuga, Naheed, Mackenzie, Francesca E., Dubis, Adam M., Georgiadis, Anastasios, Graca, Anna B., Pearson, Rachael A., Ali, Robin R., Sakami, Sanae, Palczewski, Krysztof, Sherman, Michael Y., Reeves, Philip J. and Cheetham, Michael E. (2017) Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Human Molecular Genetics, 26(2), pp. 305-319. ISSN (print) 0964-6906

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Additional Information: This work was supported by RP Fighting Blindness [grant numbers: GR580, GR572 and GR563], The BIG Lottery Fund, Fight for Sight, the Wellcome Trust [grant numbers 092621 and 099173], the National Institutes of Health [grant number EY022326] and Arnold and Mabel Beckman Foundation.
Research Area: Biological sciences
Psychiatry, neuroscience and clinical psychology
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing (until 2017)
Faculty of Science, Engineering and Computing (until 2017) > School of Life Sciences
Faculty of Science, Engineering and Computing (until 2017) > School of Pharmacy and Chemistry
Depositing User: Francesca Mackenzie
Date Deposited: 27 Nov 2017 15:29
Last Modified: 16 Feb 2018 15:29
DOI: https://doi.org/10.1093/hmg/ddw387
URI: http://eprints.kingston.ac.uk/id/eprint/39938

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