One-pot hydrogen peroxide and hydrohalic acid induced ring closure and selective aromatic halogenation to give new ring-fused benzimidazoles

Gurry, Michael, Sweeney, Martin, McArdle, Patrick and Aldabbagh, Fawaz (2015) One-pot hydrogen peroxide and hydrohalic acid induced ring closure and selective aromatic halogenation to give new ring-fused benzimidazoles. Organic Letters, 17(11), pp. 2856-2859. ISSN (print) 1523-7060

Full text available as:
[img]
Preview
Text
Al-Dabbagh-F-39240-AAM.pdf - Accepted Version

Download (589kB) | Preview

Abstract

A new series of selectively dichlorinated and dibrominated five to eight-membered ring [1,2-a] fused benzimidazoles and [1,4]oxazino[4,3-a]benzimidazoles are synthesized in mostly high yields of >80% using the reaction of hydrogen peroxide and hydrohalic acid with commercially available o-cyclic amine substituted anilines. Domestic bleach with HCl is also capable of a one-pot ring-closure and chlorination.

Item Type: Article
Research Area: Chemistry
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing (until 2017) > School of Pharmacy and Chemistry
Related URLs:
Depositing User: Fawaz Al-Dabbagh
Date Deposited: 13 Oct 2017 15:39
Last Modified: 16 Feb 2018 14:39
DOI: https://doi.org/10.1021/acs.orglett.5b01317
URI: http://eprints.kingston.ac.uk/id/eprint/39240

Actions (Repository Editors)

Item Control Page Item Control Page