Association of retinopathy and retinal microvascular abnormalities with stroke and cerebrovascular disease

Hughes, Alun D, Falaschetti, Emanuela, Witt, Nicholas, Wijetunge, Sumangali, Mc G. Thom, Simon A, Tillin, Therese, Aldington, Steve J and Chaturvedi, Nish (2016) Association of retinopathy and retinal microvascular abnormalities with stroke and cerebrovascular disease. Stroke, 47(11), pp. 2862-2864. ISSN (print) 0039-2499

Full text not available from this archive.


BACKGROUND AND PURPOSE: Abnormalities of the retinal circulation may be associated with cerebrovascular disease. We investigated associations between retinal microvascular abnormalities and (1) strokes and subclinical cerebral infarcts and (2) cerebral white matter lesions in a UK-based triethnic population-based cohort. METHODS: A total of 1185 participants (age, 68.8±6.1 years; 77% men) underwent retinal imaging and cerebral magnetic resonance imaging. Cerebral infarcts and white matter hyperintensities were identified on magnetic resonance imaging, retinopathy was graded, and retinal vessels were measured. RESULTS: Higher retinopathy grade (odds ratio [OR], 1.40 [95% confidence interval (95% CI), 1.16-1.70]), narrower arteriolar diameter (OR, 0.98 [95% CI, 0.97-0.99]), fewer symmetrical arteriolar bifurcations (OR, 0.84 [95% CI, 0.75-0.95]), higher arteriolar optimality deviation (OR, 1.16 [95% CI, 1.00-1.34]), and more tortuous venules (OR, 1.20 [95% CI, 1.09-1.32]) were associated with strokes/infarcts and white matter hyperintensities. Associations with quantitative retinal microvascular measures were independent of retinopathy. CONCLUSIONS: Abnormalities of the retinal microvasculature are independently associated with stroke, cerebral infarcts, and white matter lesions.

Item Type: Article
Research Area: Biological sciences
Cardiovascular medicine
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing (until 2017) > School of Life Sciences
Related URLs:
Depositing User: Sumangali Wijetunge
Date Deposited: 13 Jan 2017 13:24
Last Modified: 05 Jun 2017 11:01

Actions (Repository Editors)

Item Control Page Item Control Page