Relationship between air pollution and metal levels in cancerous and non-cancerous lung tissues

Binkowski, Lukasz J, Rogozinski, Pawel, Blaszczyk, Martyna, Semla, Magdalena, Melia, Patrick M and Stawarz, Robert (2016) Relationship between air pollution and metal levels in cancerous and non-cancerous lung tissues. Journal of Environmental Science and Health, Part A, Toxic/Hazardous Substances & Environmental Engineering, 51(14), pp. 1303-1308. ISSN (print) 1093-4529

Full text available as:
[img]
Preview
Text
Melia-P-35761-AAM.pdf - Accepted Version

Download (594kB) | Preview

Abstract

We aimed to check the relationships between levels of metals (Ca, Cd, Cu, Fe, Hg and Zn) in cancerous and non-cancerous lung tissues and their link to air pollution, expressed as particulate matter (PM) concentrations. The study also examines the influence on metal concentration in the lung tissue of patients' sex and the distance of their homes from the nearest emitter. We found that the general pattern of ascending concentrations in tumor tissue was as follows: Hg < Cd < Cu < Ca < Zn < Fe. In non-affected lung tissue the order of concentrations of Ca and Fe was reversed. With the exception of Cd and Cu, levels of metals were found in higher accumulations in non-cancerous tissue (e.g., Fe 326.423 and Ca 302.730 μg/g d.w) than in tumorous tissue (Fe 150.735 and Ca 15.025 μg/g d.w). Neither the PM10 (PM of a diameter of 10 μm) concentration nor sex revealed any connection with metal concentrations. The shorter the distance from the emitter, the higher the metal concentrations that tended to be observed for almost all metals, but a statistically significant (but weak) relationship was noted only for Cu in tumor tissue (rs: -0.4869).

Item Type: Article
Research Area: Biological sciences
Cancer studies
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing (until 2017) > School of Life Sciences
Faculty of Science, Engineering and Computing (until 2017) > School of Pharmacy and Chemistry
Related URLs:
Depositing User: Automatic Import Agent
Date Deposited: 25 Aug 2016 15:18
Last Modified: 17 Aug 2017 02:05
DOI: https://doi.org/10.1080/10934529.2016.1215200
URI: http://eprints.kingston.ac.uk/id/eprint/35761

Actions (Repository Editors)

Item Control Page Item Control Page