Correia repeat enclosed elements and non-coding RNAs in the Neisseria species

Roberts, Sabrina, Spencer-Smith, Russell, Shah, Mahwish, Nebel, Jean-Christophe, Cook, Richard T. and Snyder, Lori A. S. (2016) Correia repeat enclosed elements and non-coding RNAs in the Neisseria species. Microorganisms, 4(3), p. 31. ISSN (online) 2076-2607

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Neisseria gonorrhoeae is capable of causing gonorrhoea and more complex diseases in the human host. Neisseria meningitidis is a closely related pathogen that shares many of the same genomic features and virulence factors, but causes the life threatening diseases meningococcal meningitis and septicaemia. The importance of non-coding RNAs in gene regulation has become increasingly evident having been demonstrated to be involved in regulons responsible for iron acquisition, antigenic variation, and virulence. Neisseria spp. contain an IS-like element, the Correia Repeat Enclosed Element, which has been predicted to be mobile within the genomes or to have been in the past. This repeat, present in over 100 copies in the genome, has the ability to alter gene expression and regulation in several ways. We reveal here that Correia Repeat Enclosed Elements tend to be near non-coding RNAs in the Neisseria spp., especially N. gonorrhoeae. These results suggest that Correia Repeat Enclosed Elements may have disrupted ancestral regulatory networks not just through their influence on regulatory proteins but also for non-coding RNAs.

Item Type: Article
Research Area: Biological sciences
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing (until 2017) > School of Life Sciences
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Depositing User: Katrina Clifford
Date Deposited: 27 Sep 2016 14:36
Last Modified: 27 Jun 2017 12:50

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