Adding functionality with additive manufacturing : fabrication of titanium-based antibiotic eluting implants

Cox, Sophie C, Jamshidi, Parastoo, Eisenstein, Neil M, Webber, Mark A, Hassanin, Hany, Attallah, Moataz M, Shepherd, Duncan E T, Addison, Owen and Grover, Liam M (2016) Adding functionality with additive manufacturing : fabrication of titanium-based antibiotic eluting implants. Materials Science & Engineering C - Materials for Biological Applications, 64, pp. 407-415. ISSN (print) 0928-4931

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Additive manufacturing technologies have been utilised in healthcare to create patient-specific implants. This study demonstrates the potential to add new implant functionality by further exploiting the design flexibility of these technologies. Selective laser melting was used to manufacture titanium-based (Ti-6Al-4V) implants containing a reservoir. Pore channels, connecting the implant surface to the reservoir, were incorporated to facilitate antibiotic delivery. An injectable brushite, calcium phosphate cement, was formulated as a carrier vehicle for gentamicin. Incorporation of the antibiotic significantly (p=0.01) improved the compressive strength (5.8±0.7MPa) of the cement compared to non-antibiotic samples. The controlled release of gentamicin sulphate from the calcium phosphate cement injected into the implant reservoir was demonstrated in short term elution studies using ultraviolet-visible spectroscopy. Orientation of the implant pore channels were shown, using micro-computed tomography, to impact design reproducibility and the back-pressure generated during cement injection which ultimately altered porosity. The amount of antibiotic released from all implant designs over a 6hour period (<28% of the total amount) were found to exceed the minimum inhibitory concentrations of Staphylococcus aureus (16μg/mL) and Staphylococcus epidermidis (1μg/mL); two bacterial species commonly associated with periprosthetic infections. Antibacterial efficacy was confirmed against both bacterial cultures using an agar diffusion assay. Interestingly, pore channel orientation was shown to influence the directionality of inhibition zones. Promisingly, this work demonstrates the potential to additively manufacture a titanium-based antibiotic eluting implant, which is an attractive alternative to current treatment strategies of periprosthetic infections.

Item Type: Article
Additional Information: The authors would like to acknowledge the Engineering and Physical Sciences Research Council (grant number EP/L020815/1) for funding this research.
Research Area: Chemical engineering
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing (until 2017) > School of Mechanical and Automotive Engineering
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Depositing User: Automatic Import Agent
Date Deposited: 04 May 2016 15:37
Last Modified: 05 Apr 2017 02:30

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