Digalactoside expression in the lipopolysaccharide of ' Haemophilus influenzae ' and its role in intravascular survival

Griffin, Ruth, Bayliss, Chris D., Herbert, Mark A., Cox, Andrew D., Makepeace, Katherine, Richards, James C., Hood, Derek W. and Moxon, E. Richard (2005) Digalactoside expression in the lipopolysaccharide of ' Haemophilus influenzae ' and its role in intravascular survival. Infection And Immunity, 73(10), pp. 7022-7026. ISSN (print) 0019-9567

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Abstract

Digalactoside (galα-1-4 galβ) structures of the lipopolysaccharide (LPS) of Haemophilus influenzae are implicated in virulence. A confounding factor is that tetranucleotide repeats within the lic2A, lgtC, and lex2 genes mediate phase-variable expression of the digalactosides. By deleting these repeats, we constructed recombinant strains of RM153 constitutively expressing either one or two LPS digalactosides. Expression of two digalactosides, rather than one, was associated with increased virulence of H. influenzae in vivo.

Item Type: Article
Additional Information: This work was supported by the Medical Research Council.
Research Area: Biological sciences
Faculty, School or Research Centre: Faculty of Science (until 2011)
Depositing User: Ruth Griffin
Date Deposited: 07 Apr 2017 09:15
Last Modified: 07 Apr 2017 09:23
DOI: https://doi.org/10.1128/IAI.73.10.7022-7026.2005
URI: http://eprints.kingston.ac.uk/id/eprint/33835

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