Signature-tagged transposon mutagenesis identifies novel ' Mycobacterium tuberculosis ' genes involved in the parasitism of human macrophages

Rosas-Magallanes, Vania, Stadthagen-Gomez, Gustavo, Rauzier, Jean, Barreiro, Luis B., Tailleux, Ludovic, Boudou, Frederic, Griffin, Ruth, Nigou, Jerome, Jackson, Mary, Gicquel, Brigitte and Neyrolles, Olivier (2007) Signature-tagged transposon mutagenesis identifies novel ' Mycobacterium tuberculosis ' genes involved in the parasitism of human macrophages. Infection And Immunity, 75(1), pp. 504-507. ISSN (print) 0019-9567

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Abstract

Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells.

Item Type: Article
Additional Information: This work was supported by Institut Pasteur and the European Community [contracts QLK2-CT-2001-02018 and QLK2-CT-2000- 01761].
Research Area: Biological sciences
Faculty, School or Research Centre: Faculty of Science (until 2011)
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Depositing User: Ruth Griffin
Date Deposited: 07 Apr 2017 09:22
Last Modified: 07 Apr 2017 09:22
URI: http://eprints.kingston.ac.uk/id/eprint/33824

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