Sensory protein kinase signalling in ' Schistosoma mansoni ' Cercariae : host location and invasion

Ressurreicao, Margarida, Kirk, Ruth S, Rollinson, David, Emery, Aidan M, Page, Nigel M and Walker, Anthony J (2015) Sensory protein kinase signalling in ' Schistosoma mansoni ' Cercariae : host location and invasion. The Journal of Infectious Diseases, 212(11), pp. 1787-1797. ISSN (print) 0022-1899

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Schistosoma mansoni cercariae display specific behavioural responses to abiotic/biotic stimuli enabling them to locate and infect the definitive human host. Here we report the effect of such stimulants on signalling pathways of cercariae in relation to host finding and invasion. Cercariae exposed to various light/temperature regimes displayed modulated protein kinase C (PKC), extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (p38 MAPK) activities, with distinct responses at 37°C and intense light/dark, when compared to 24°C under normal light. Kinase activities were localized to regions including the oral sensory papillae, acetabular ducts, tegument, acetabular glands, and nervous system. Furthermore, linoleic acid (LA) modulated PKC and ERK activities concurrent with the temporal release of acetabular gland components. Attenuation of PKC, ERK and p38 MAPK activities significantly reduced gland component release, particularly in response to LA, demonstrating the importance of these signalling pathways to host penetration mechanisms.

Item Type: Article
Uncontrolled Keywords: schistosoma mansoni, schistosomiasis, protein kinase c, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, cell signaling, linoleic acid, temperature, light, cercariae
Research Area: Allied health professions and studies
Epidemiology and public health
Other laboratory based clinical subjects
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing (until 2017) > School of Life Sciences
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Depositing User: Automatic Import Agent
Date Deposited: 28 Sep 2015 13:28
Last Modified: 27 Sep 2016 13:32

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