Relationship between insulin resistance and circulating endothelial cells in pre-eclampsia.

Anim-Nyame, Nick, Ghosh, Anshuman, Freestone, Nicholas and Arrigoni, Francesca (2015) Relationship between insulin resistance and circulating endothelial cells in pre-eclampsia. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 31(10), pp. 788-791. ISSN (print) 1473-0766

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Abstract

Endothelial dysfunction and insulin resistance (IR) are established features of pre-eclampsia, however the cause and effect relationship between them remain unexplained. Circulating endothelial cells (CEC) are increased in pre-eclampsia and appear to correlate with the degree of endothelial dysfunction. We hypothesised that CEC count in pre-eclampsia would correlate with IR and might provide a simple measure of IR in pregnancies complicated by the disease. CEC count and IR were measured in 10 women with pre-eclampsia and 10 normal pregnant controls matched for maternal age, body mass index and gestational age during the third trimester. CEC count was determined using an established immunomagnetic bead separation method and IR was measured by the homeostasis model test. CEC count and IR were significantly increased in pre-eclampsia compared to normal pregnancy. However, there was no correlation between the CEC count and IR in pre-eclampsia. The data suggest that CEC count in pre-eclampsia is not a useful measure on its own of IR in pregnancies complicated by the disease.

Item Type: Article
Uncontrolled Keywords: circulating endothelial cells, endothelial dysfunction, insulin resistance, pre-eclampsia
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing (until 2017)
Faculty of Science, Engineering and Computing (until 2017) > School of Life Sciences
Faculty of Science, Engineering and Computing (until 2017) > School of Pharmacy and Chemistry
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Depositing User: Automatic Import Agent
Date Deposited: 24 Jul 2015 08:10
Last Modified: 12 Aug 2016 13:21
DOI: https://doi.org/10.3109/09513590.2015.1065477
URI: http://eprints.kingston.ac.uk/id/eprint/32147

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