Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in Polymicrobial sepsis

Lambden, Simon, Kelly, Peter, Ahmetaj-Shala, Blerina, Wang, Zhen, Lee, Benjamin, Nandi, Manasi, Torondel, Belen, Delahaye, Matthew, Dowsett, Laura, Piper, Sophie, Tomlinson, James, Caplin, Ben, Colman, Lucy, Boruc, Olga, Slaviero, Anna, Zhao, Lan, Oliver, Eduardo, Khadayate, Sanjay, Singer, Mervyn, Arrigoni, Francesca and Leiper, James (2015) Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in Polymicrobial sepsis. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(6), pp. 1382-1392. ISSN (print) 1079-5642

Abstract

Ddah2 has a regulatory role both in normal physiology and in determining outcome of severe polymicrobial sepsis. Elucidation of this role identifies a mechanism for the observed relationship between Ddah2 polymorphisms, cardiovascular disease, and outcome in sepsis.

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