Regulation and function of adhesion molecules in B-cell chronic lymphocytic leukaemia

Jewell, A P and Yong, K L (1997) Regulation and function of adhesion molecules in B-cell chronic lymphocytic leukaemia. Acta Haematologica, 97(1-2), pp. 67-72. ISSN (print) 0001-5792

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Cell surface expression of adhesion molecules in B-cell chronic lymphocytic leukemia (B-CLL) may determine the patterns of dissemination and infiltration. B-CLL cells express high levels of CD44, but expression of the leucocyte integrins was low or absent, while expression of VLA-4 is high. Most cases examined expressed no detectable ICAM-1, but some cases demonstrated levels of up to 30%. Levels of L-selectin were also variable, and expression could be induced/enhanced in vitro by incubation with cytokines such as IL-4, interferon-alpha and interferon-gamma. B-CLL cells bound normally to vascular endothelium, but binding to IL-1-activated endothelium was significantly lower than that of normal peripheral blood lymphocytes. Cytokine enhancement of L-selectin expression was not accomplished by changes in binding to vascular endothelium. Patterns of adhesion molecule expression and their regulation by cytokines may underly some of the clinical features of this disease.

Item Type: Article
Additional Information: ISBN: 9783805563932
Uncontrolled Keywords: adhesion molecules, b-cell chronic lymphocytic, leukaemia, integrins, selectins, vascular endothelium, non-hodgkins lymphoma, leukemia cells, homing receptor, expression, mechanisms, metastasis, migration, integrins, disease
Research Area: Chemistry
Cancer studies
Allied health professions and studies
Faculty, School or Research Centre: Faculty of Health and Social Care Sciences (until 2013)
Related URLs:
Depositing User: Kim Forbes
Date Deposited: 28 Jul 2008
Last Modified: 13 Jul 2010 11:17

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