Neuroprotective effect of honokiol and magnolol, compounds from 'Magnolia officinalis', on beta-amyloid-induced toxicity in PC12 cells

Hoi, Chu Peng, Ho, Yee Ping, Baum, Larry and Chow, Albert H. L. (2010) Neuroprotective effect of honokiol and magnolol, compounds from 'Magnolia officinalis', on beta-amyloid-induced toxicity in PC12 cells. Phytotherapy Research, 24(10), pp. 1538-1542. ISSN (print) 0951-418X

Full text not available from this archive.

Abstract

Amyloid [beta] peptide (A[beta]) induced toxicity is a well-established pathway of neuronal cell death which might play a role in Alzheimer's disease. In this regard, the toxic effect of A[beta] on a cultured A[beta] -sensitive neuronal cell line was used as a primary screening tool for potential anti-Alzheimer's therapeutic agents. The effects of nine pure compounds (vitamin E, α-asarone, salidroside, baicolin, magnolol, gastrodin, bilobalide, honokiol and [beta]-asarone) from selected Chinese herbs on neuronal cell death induced by A[beta] in NGF-differentiated PC12 cells were examined. Only two of the studied compounds, honokiol and magnolol, significantly decreased A[beta]-induced cell death. Further experiments indicated that their neuroprotective effects are possibly mediated through reduced ROS production as well as suppression of intracellular calcium elevation and inhibition of caspase-3 activity. The results provide for the first time a scientific rationale for the clinical use of honokiol and magnolol in the treatment of Alzheimer's disease.

Item Type: Article
Research Area: Chemistry
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing (until 2017) > School of Pharmacy and Chemistry
Related URLs:
Depositing User: Gemma Sansom
Date Deposited: 02 Jan 2013 15:40
Last Modified: 02 Jan 2013 15:40
DOI: https://doi.org/10.1002/ptr.3178
URI: http://eprints.kingston.ac.uk/id/eprint/24433

Actions (Repository Editors)

Item Control Page Item Control Page