Positron emission tomography in schizophrenia: a new perspective

Patel, N. H., Vyas, N. S., Puri, B. K., Nijran, K. S. and Al-Nahhas, A. (2010) Positron emission tomography in schizophrenia: a new perspective. Journal of Nuclear Medicine, 51(4), pp. 511-520. ISSN (print) 0161-5505

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PET is an important functional imaging technique that can be used to investigate neurotransmitter receptors and transporters directly by mapping human brain function. PET is increasingly being used greatly to advance our understanding of the neurobiology and pathophysiology of schizophrenia. METHODS: This review focuses on the use of PET tracers and kinetic modeling in identifying regional brain abnormalities and regions associated with cognitive functioning in schizophrenia. A variety of PET tracers have been used to identify brain abnormalities, including (11)C, (15)O-water, (18)F-fallypride, and L-3,4-dihydroxy-6-(18)F-fluorophenylalanine ((18)F-FDOPA). RESULTS: Some studies have used compartmental modeling to determine tracer binding kinetics. The most consistent findings show a difference in the dopamine content in the prefrontal cortex, anterior cingulate gyrus, and hippocampus between healthy controls and patients with schizophrenia. Studies also show a higher density of D(2) receptors in the striatum and neural brain dysconnectivity. CONCLUSION: Future investigations integrating clinical, imaging, genetic, and cognitive aspects are warranted to gain a better understanding of the pathophysiology of this disorder.

Item Type: Article
Research Area: Physics
Psychiatry, neuroscience and clinical psychology
Faculty, School or Research Centre: Faculty of Arts and Social Sciences (until 2017) > School of Social Science (until November 2012)
Related URLs:
Depositing User: Nora Vyas
Date Deposited: 11 Dec 2012 15:20
Last Modified: 18 Dec 2012 15:02
DOI: https://doi.org/10.2967/jnumed.109.066076
URI: http://eprints.kingston.ac.uk/id/eprint/23795

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