Fatty acid flux and oxidation are increased by rimonabant in obese women.

Backhouse, Katharine, Sarac, Ivana, Shojaee-Moradie, Fariba, Stolinski, Michael, Robertson, M Denise, Frost, Gary S, Bell, Jimmy D, Thomas, E Louise, Wright, John, Russell-Jones, David and Umpleby, A Margot (2012) Fatty acid flux and oxidation are increased by rimonabant in obese women. Metabolism: Clinical and Experimental, 61(9), pp. 1220-1223. ISSN (print) 0026-0495

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This study aimed to determine in obese women if endocannabinoid receptor antagonism has effects on fatty acid and triglyceride metabolism and insulin sensitivity which are independent from the metabolic effects of weight loss. Fourteen obese (BMI=33.0±0.5 kg/m(2)) (mean±SEM) Caucasian post-menopausal women, aged 57.8±4.7 years were studied. The women were randomised to 2 groups, one group received the endocannabinoid receptor antagonist rimonabant (20 mg/d) for 12 weeks. A control group achieved the same weight loss by a hypocaloric dietary intervention over 12 weeks. Palmitate production rate (Ra), a measure of lipolysis, and palmitate oxidation rate, and VLDL(1) and VLDL(2) triglyceride (TG) kinetics, were measured using isotopic tracers before and after the intervention. Weight loss was not different in the 2 groups; 2.6±0.5 kg with rimonabant and 3.1±1.0 kg in the control group. Palmitate Ra increased with rimonabant with no change in the control group (p=0.03 between groups). Palmitate oxidation rate increased with rimonabant but decreased in the control group (p=0.005 between groups). VLDL(1) TG secretion rate decreased in the control group and increased in the rimonabant group (p=0.008 between groups). There was no significant effect on insulin sensitivity. This study suggests that endocannabinoid receptor antagonism for 12 weeks in obese women increased lipolysis and fatty acid oxidation. The increase in VLDL(1) TG secretion rate may be due to the increase in lipolysis which exceeded the increase in fatty acid oxidation.

Item Type: Article
Research Area: Allied health professions and studies
Other laboratory based clinical subjects
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing (until 2017)
Faculty of Science, Engineering and Computing (until 2017) > School of Life Sciences
Depositing User: Michael Stolinski
Date Deposited: 26 Jul 2012 10:51
Last Modified: 08 Feb 2013 09:22
DOI: https://doi.org/10.1016/j.metabol.2012.02.012
URI: http://eprints.kingston.ac.uk/id/eprint/23249

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