Grootveld, M, Claxson, A, Naughton, D, Whelan, M, Furst, A and Blake, D (1991) Influence of intravenous aurothiomalate on the status of low-molecular-mass endogenous metabolites in blood plasma: a proton nuclear magnetic resonance study. In: Satellite Symposium of the 9th International Congress of Pharmacology: Drugs in Inflammation; 28-29 Jun, 1990, Noordwijk, Netherlands. (Agents and Actions Supplements, no. 32)

Abstract

The effect of aurothiomalate on the status of a wide range of low-molecular-mass endogenous metabolites in blood plasma obtained from animals treated with an intravenous dose of this second-line agent (150 mg/kg) has been assessed by high field proton Hahn spin-echo NMR spectroscopy. As well as modulating the effective concentrations of NMR-detectable biomolecules, aurothiomalate induces a time-dependent decrease in plasma levels of triacylglycerols with a corresponding elevation in the concentration of the ketone body 3-D-hydroxybutyrate, indicating an increased utilisation of fats for energy in rats treated with this 1:1 gold(I)-thiolate complex. These observations may reflect the toxic side-effects that are associated with aurothiomalate treatment.

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