Novel inhibitors of the enzyme estrone sulfatase (ES)

Ahmed, Sabbir, James, Karen, Owen, Caroline P., Patel, Chirag and Patel, Mijal (2001) Novel inhibitors of the enzyme estrone sulfatase (ES). Bioorganic & Medicinal Chemistry Letters, 11(6), pp. 841-844. ISSN (print) 0960-894X

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We report the initial results of our study into a series of simple 4-sulfamated phenyl alkyl ketones as potential inhibitors of the enzyme estrone sulfatase. The results of the study show that these compounds are potent inhibitors, possessing greater inhibitory activity than COUMATE, but weaker activity than EMATE. Furthermore, the compounds are observed to be irreversible inhibitors.

Item Type: Article
Uncontrolled Keywords: aromatase inhibitors, steroid sulfatase
Research Area: Allied health professions and studies
Faculty, School or Research Centre: Faculty of Science (until 2011) > School of Pharmacy and Chemistry
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Depositing User: David Salliss
Date Deposited: 26 Jun 2007
Last Modified: 19 Nov 2010 15:06

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