Caprifico, Anna E., Polycarpou, Elena, Foot, Peter J. S. and Calabrese, Gianpiero (2020) Fluorescein isothiocyanate chitosan nanoparticles in oral drug delivery studies. Trends in Pharmacological Sciences, 41(10), pp. 686-689. ISSN (print) 0165-6147

Abstract

Oral administration of drugs is one of the most patient-friendly drug delivery routes. However, drug bioavailability via the oral route remains poor due to the harsh gastrointestinal environment. In recent years, many nanocarriers have been designed to overcome this limitation. Among those, chitosan nanoparticles (ChNPs) have proved to be a quite popular choice. Here, we highlight the use of fluorescein isothiocyanate–tagged ChNPs as an invaluable tool to monitor the fate of ChNPs encapsulating oral drugs, leading to an in-depth understanding of drug biodistribution and, in turn, shedding light on ways to improve bioavailability.

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Official URL:	https://doi.org/10.1016/j.tips.2020.07.005
Item Type:	Article
Uncontrolled Keywords:	Fluorescein isothiocyanate; chitosan nanoparticles; drug bioavailability; oral delivery
Research Area:	Research Areas > Biological sciences Research Areas > Pharmacy
Faculty, School or Research Centre:	Faculty of Science, Engineering and Computing Faculty of Science, Engineering and Computing > School of Life Sciences, Pharmacy and Chemistry
Date Deposited:	04 Aug 2020 15:40
Last Modified:	07 Mar 2022 16:32
DOI:	https://doi.org/10.1016/j.tips.2020.07.005
URI:	https://eprints.kingston.ac.uk/id/eprint/46700

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