Roberts, S. and Snyder, L. (2012) Comparison of the locations of Correia Repeat Enclosed Elements and potential small noncoding RNAs in the 'Neisseria' spp. In: XVIIIth International Pathogenic Neisseria Conference (IPNC); 09 - 14 Sep 2012, Würzburg, Germany. (Unpublished)

Abstract

Small noncoding RNAs do not code for proteins, but have been shown to perform regulatory roles in the cell, including the regulation of processes such as secretion and virulence. A small noncoding RNA,nrrF, that mediates Fur-dependant regulation of succinate dehydrogenase has been previously identified in Neisseria meningitidis. Deep sequencing of transcriptomes has revealed small noncoding RNAs in both N. meningitidis and Neisseria gonorrheoae. A small noncoding RNA, Hfq found in N. meningitidis is up-regulated during incubation in blood suggesting that noncoding RNAs might also play a role in N. meningitidis infection. Analysis of differential expression in intergenic regions showed enhanced transcription of a novel non-coding RNA molecule of 74 nucleotides, involved in the riboregulation of target mRNAs. Research on Correia Repeat Enclosed Elements in the Neisseria spp. has shown that many of them are 5’ of genes and possess functional promoter elements. A comparison of available neisserial genome sequences was undertaken to see if Correia Repeat Enclosed Elements were found at similar positions to predicted and previously identified small noncoding RNAs. A high correlation between the locations of small noncoding RNAs and Correia Repeat Enclosed Element was seen in some strains.

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