Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes

Rossiter, Sharon, Peron, Jean-Marie, Whitfield, Philip J. and Jones, Keith (2005) Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes. Bioorganic & Medicinal Chemistry Letters, 15(21), pp. 4806-4808. ISSN (print) 0960-894X

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Abstract

2,4-Disubstituted quinolines with additional substituents in positions 5-8 have been found to have anthelmintic properties. A number of 2,4-dimethoxy-6- or 8-arylquinolines have potent activity against the sheep nematode 'Haemonchus contortus', with LD99 values of the same order of magnitude as levamisole. These arylquinolines maintain their activity against levamisole-, ivermectin- and thiabendazole-resistant strains of 'H. contortus'.

Item Type: Article
Additional Information: This work was supported by the Wellcome Trust.
Uncontrolled Keywords: Quinolines; Suzuki coupling; Anthelmintics, Atanine
Research Area: Chemistry
Biological sciences
Faculty, School or Research Centre: Faculty of Science (until 2011) > School of Pharmacy and Chemistry
Related URLs:
Depositing User: Jean-Marie Peron
Date Deposited: 12 Nov 2010 10:56
Last Modified: 20 Jan 2012 12:04
URI: http://eprints.kingston.ac.uk/id/eprint/9506

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