Rossiter, Sharon, Peron, Jean-Marie, Whitfield, Philip J. and Jones, Keith (2005) Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes. Bioorganic & Medicinal Chemistry Letters, 15(21), pp. 4806-4808. ISSN (print) 0960-894XFull text not available from this archive.
2,4-Disubstituted quinolines with additional substituents in positions 5-8 have been found to have anthelmintic properties. A number of 2,4-dimethoxy-6- or 8-arylquinolines have potent activity against the sheep nematode 'Haemonchus contortus', with LD99 values of the same order of magnitude as levamisole. These arylquinolines maintain their activity against levamisole-, ivermectin- and thiabendazole-resistant strains of 'H. contortus'.
|Additional Information:||This work was supported by the Wellcome Trust.|
|Uncontrolled Keywords:||Quinolines; Suzuki coupling; Anthelmintics, Atanine|
|Faculty, School or Research Centre:||Faculty of Science (until 2011) > School of Pharmacy and Chemistry|
|Depositing User:||Jean-Marie Peron|
|Date Deposited:||12 Nov 2010 10:56|
|Last Modified:||20 Jan 2012 12:04|
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