Rossiter, Sharon, Peron, Jean-Marie, Whitfield, Philip J. and Jones, Keith (2005) Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes. Bioorganic & Medicinal Chemistry Letters, 15(21), pp. 4806-4808. ISSN (print) 0960-894X
Full text not available from this archive.Abstract
2,4-Disubstituted quinolines with additional substituents in positions 5-8 have been found to have anthelmintic properties. A number of 2,4-dimethoxy-6- or 8-arylquinolines have potent activity against the sheep nematode 'Haemonchus contortus', with LD99 values of the same order of magnitude as levamisole. These arylquinolines maintain their activity against levamisole-, ivermectin- and thiabendazole-resistant strains of 'H. contortus'.
| Item Type: | Article |
|---|---|
| Additional Information: | This work was supported by the Wellcome Trust. |
| Uncontrolled Keywords: | Quinolines; Suzuki coupling; Anthelmintics, Atanine |
| Research Area: | Chemistry Biological sciences |
| Faculty, School or Research Centre: | Faculty of Science (until 2011) > School of Pharmacy and Chemistry |
| Related URLs: | |
| Depositing User: | Jean-Marie Peron |
| Date Deposited: | 12 Nov 2010 10:56 |
| Last Modified: | 20 Jan 2012 12:04 |
| URI: | http://eprints.kingston.ac.uk/id/eprint/9506 |
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