Ahmed, Sabbir and Owen, Caroline P. (1998) Mechanism of 17[alpha]-hydroxylase/17,20-lyase--an initial geometric perspective for the lyase of the C(17)-C(20) bond of C[sub]21 steroids. Bioorganic & Medicinal Chemistry Letters, 8(9), pp. 1023-1028. ISSN (print) 0960-894X
Full text not available from this archive.Abstract
Using the novel 'substrate-heme complex' approach, the mechanism of 17 alpha-Hydroxylase/17,20-Lyase (P-450(17) alpha), in particular the lyase of the C(17)-C(20) bond, is considered from a geometric perspective. The results of the study appear to suggest that the final oxidative step in the lyase of the C(17)-C(20) bond involves the use of a ferroxy attacking species as opposed to peroxy or a mixture of ferroxy and peroxy, an observation which is consistent with results previously obtained with Aromatase.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | inhibitors, aromatase |
| Research Area: | Chemistry |
| Faculty, School or Research Centre: | Faculty of Science (until 2011) > School of Pharmacy and Chemistry |
| Related URLs: | |
| Depositing User: | Automatic Import Agent |
| Date Deposited: | 18 Mar 2010 14:40 |
| Last Modified: | 14 Apr 2011 12:21 |
| URI: | http://eprints.kingston.ac.uk/id/eprint/7278 |
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