The use of the novel substrate-heme complex approach in the derivation of a representation of the active site of the enzyme cholesterol side chain cleavage

Ahmed, Sabbir (2000) The use of the novel substrate-heme complex approach in the derivation of a representation of the active site of the enzyme cholesterol side chain cleavage. Biochemical and Biophysical Research Communications, 274(3), pp. 821-824. ISSN (print) 0006-291X

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Abstract

The previously reported substrate-heme complex approach is used to study the binding of type II inhibitors of the enzyme cholesterol side chain cleavage (CSCC), a cytochrome P-450 dependent enzyme involved in the oxidative cleaveage of the C(20)-C(22) bond of cholesterol. Using the derived model, we have rationalised the inhibitory activity of a number of compounds including aminoglutethimide and pyridoglutethimide and the enantiomers of ketoconazole.

Item Type: Article
Uncontrolled Keywords: molecular modeling perspective, aromatase, inhibitors, mechanism
Research Area: Chemistry
Faculty, School or Research Centre: Faculty of Science (until 2011) > School of Pharmacy and Chemistry
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Depositing User: Automatic Import Agent
Date Deposited: 16 Mar 2010 08:13
Last Modified: 08 Apr 2011 11:16
URI: http://eprints.kingston.ac.uk/id/eprint/7242

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