Ahmed, Sabbir (2000) The use of the substrate-heme complex approach in the design, synthesis, biochemical evaluation, and rationalization of the inhibitory activity of a range of azole compounds against cholesterol side chain cleavage enzyme. Biochemical and Biophysical Research Communications, 275(1), pp. 75-76. ISSN (print) 0006-291XFull text not available from this archive.
Here, we report the synthesis and biochemical evaluation of a number of compounds as potent inhibitors of cytochrome P450 enzymes, such as aromatase (AR), but not cholesterol side chain cleavage (CSCC). This is a crucial enzyme in the steroidal cascade and its inhibition results in major side-effects, as a result, the ability of compounds to specifically inhibit enzymes such as AR but not CSCC would be an important factor in the drug design process.
|Uncontrolled Keywords:||molecular modeling perspective, aromatase, mechanism|
|Faculty, School or Research Centre:||Faculty of Science (until 2011) > School of Pharmacy and Chemistry|
|Depositing User:||Automatic Import Agent|
|Date Deposited:||16 Mar 2010 08:08|
|Last Modified:||08 Apr 2011 11:19|
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