Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism

Ahmed, Sabbir, James, Karen, Owen, Caroline P., Patel, Chirag K. and Patel, Mijal B. (2001) Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism. Bioorganic & Medicinal Chemistry Letters, 11(23), pp. 3001-3005. ISSN (print) 0960-894X

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Abstract

Using the postulated mechanism for the enzyme estrone sulfatase (ES), we have determined a possible transition state for the reaction catalysed by ES as a representation of the active site. Using the derived structure, we have undertaken the molecular modelling of several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.

Item Type: Article
Uncontrolled Keywords: steroid sulfatase, inhibitors, estrone-3-o-sulfamate
Research Area: Chemistry
Faculty, School or Research Centre: Faculty of Science (until 2011) > School of Pharmacy and Chemistry
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Depositing User: Automatic Import Agent
Date Deposited: 11 Mar 2010 11:28
Last Modified: 14 Apr 2011 12:09
URI: http://eprints.kingston.ac.uk/id/eprint/7218

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