Ahmed, Sabbir, James, Karen, Owen, Caroline P., Patel, Chirag K. and Patel, Mijal B. (2001) Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism. Bioorganic & Medicinal Chemistry Letters, 11(23), pp. 3001-3005. ISSN (print) 0960-894X
Full text not available from this archive.Abstract
Using the postulated mechanism for the enzyme estrone sulfatase (ES), we have determined a possible transition state for the reaction catalysed by ES as a representation of the active site. Using the derived structure, we have undertaken the molecular modelling of several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | steroid sulfatase, inhibitors, estrone-3-o-sulfamate |
| Research Area: | Chemistry |
| Faculty, School or Research Centre: | Faculty of Science (until 2011) > School of Pharmacy and Chemistry |
| Related URLs: | |
| Depositing User: | Automatic Import Agent |
| Date Deposited: | 11 Mar 2010 11:28 |
| Last Modified: | 14 Apr 2011 12:09 |
| URI: | http://eprints.kingston.ac.uk/id/eprint/7218 |
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