Tyrrell, Elizabeth, Tesfa, Kibur Hunie, Greenwood, Iain and Mann, Alistair (2008) The synthesis and biological evaluation of a range of novel functionalised benzopyrans as potential potassium channel activators. Bioorganic & Medicinal Chemistry Letters, 18(3), pp. 1237-1240. ISSN (print) 0960-894XFull text not available from this archive.
A range of novel benzopyrans have been synthesised and biologically evaluated for K(ATP) channel activity employing cromakalim 1 as a benchmark K(ATP) channel opener. Although the compounds that were evaluated demonstrated a reduced ability to relax phenylephrine stimulated rat thoracic tissue, we provide evidence that benzopyrans 7a-h may be operating via an alternative mechanism than ATP-sensitive K(+) channel activity.
|Faculty, School or Research Centre:||Faculty of Science (until 2011) > School of Pharmacy and Chemistry|
|Depositing User:||Automatic Import Agent|
|Date Deposited:||09 Feb 2010 09:00|
|Last Modified:||08 Oct 2010 10:52|
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