The synthesis and biological evaluation of a range of novel functionalised benzopyrans as potential potassium channel activators

Tyrrell, Elizabeth, Tesfa, Kibur Hunie, Greenwood, Iain and Mann, Alistair (2008) The synthesis and biological evaluation of a range of novel functionalised benzopyrans as potential potassium channel activators. Bioorganic & Medicinal Chemistry Letters, 18(3), pp. 1237-1240. ISSN (print) 0960-894X

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Abstract

A range of novel benzopyrans have been synthesised and biologically evaluated for K(ATP) channel activity employing cromakalim 1 as a benchmark K(ATP) channel opener. Although the compounds that were evaluated demonstrated a reduced ability to relax phenylephrine stimulated rat thoracic tissue, we provide evidence that benzopyrans 7a-h may be operating via an alternative mechanism than ATP-sensitive K(+) channel activity.

Item Type: Article
Research Area: Chemistry
Faculty, School or Research Centre: Faculty of Science (until 2011) > School of Pharmacy and Chemistry
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Depositing User: Automatic Import Agent
Date Deposited: 09 Feb 2010 09:00
Last Modified: 08 Oct 2010 10:52
URI: http://eprints.kingston.ac.uk/id/eprint/7017

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