The use of albumin solid dispersion to enhance the solubility of unionisable drugs

Khoder, Mouhamad, Abdelkader, Hamdy, ElShaer, Amr, Karam, Ayman, Najlah, Mohammad and Alany, Raid G. (2017) The use of albumin solid dispersion to enhance the solubility of unionisable drugs. Pharmaceutical Development and Technology, ISSN (print) 1083-7450 (Epub Ahead of Print)

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Abstract

In this study, solid dispersions of prednisolone (PRD) and bovine serum albumin (BSA) were prepared by spray drying and freeze drying methods using a PRD:BSA solution [20:1 molar ratio (MR)]. PRD-BSA dispersed mixtures were characterized by scanning electron microscopy (SEM), and powder X-ray diffraction (XRD), and differential scanning calorimetry (DSC). PRD-BSA physical and dispersed mixtures showed significantly higher solubility in water than that of unprocessed drug. Enhancement factor of six was obtained in both physical mixture and solid dispersion solubility studies. In-vitro dissolution and release studies under physiological conditions showed an immediate release of PRD from the solid dispersions, with almost 90% of the drug dissolved in the first 10 min. PRD was immediately released from BSA binding complex. This study demonstrates the potential for the use of BSA to enhance the solubility and dissolution rate, hence bioavailability, of the unionizable drugs.

Item Type: Article
Research Area: Pharmacy
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing > School of Pharmacy and Chemistry
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Depositing User: Mouhamad Khoder
Date Deposited: 21 Sep 2017 10:41
Last Modified: 18 Oct 2017 12:56
URI: http://eprints.kingston.ac.uk/id/eprint/39209

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