Cytokines: promoters and dampeners of autoimmunity

Hill, Natasha and Sarvetnick, Nora (2002) Cytokines: promoters and dampeners of autoimmunity. Current Opinion in Immunology, 14(6), pp. 791-797. ISSN (print) 0952-7915

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Abstract

Cytokines are the co-ordinators of the immune system and, as such, are important targets for immunomodulation. Progress has been made towards the use of IL-10 for immunosuppressive therapy to prevent autoimmunity. Interest has also recently focused on the role of cytokines in controlling the activation of dendritic cells and NK cells, and the consequences of this for the development of autoaggressive responses. Genes involved in IFN-activated pathways that control the survival of lymphocytes have been strongly linked to lupus susceptibility, and IFN-mediated defenses against viral infection have been shown to determine susceptibility to a model of viral-induced diabetes.

Item Type: Article
Research Area: Biological sciences
Faculty, School or Research Centre: Faculty of Science (until 2011) > School of Life Sciences
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Depositing User: Natasha Hill
Date Deposited: 16 Jun 2017 10:05
Last Modified: 16 Jun 2017 10:05
URI: http://eprints.kingston.ac.uk/id/eprint/38358

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