The target tissue in autoimmunity : an influential niche

Hill, Natasha J., Hultcranz, Monica, Sarvetnick, Nora and Flodstrom-Tullberg, Malin (2007) The target tissue in autoimmunity : an influential niche. European Journal of Immunology, ISSN (print) 0014-2980

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Abstract

Central and peripheral tolerance mechanisms were for a long time the only regulatory circuits known in autoimmunity. It is now becoming clear that the target tissue itself may have the capacity to control its own destiny. Here we review mechanisms by which the target tissue regulates local inflammation, and the way this could influence progression to overt autoimmunity. Moreover, we discuss recent data showing that physiological properties of the target tissue can determine the organ specificity of autoimmune disease. These recent discoveries and ideas concerning the regulatory potential of the target tissue may, in the future, add a new dimension to our concept of regulatory circuits in autoimmunity.

Item Type: Article
Research Area: Biological sciences
Faculty, School or Research Centre: Faculty of Science (until 2011) > School of Life Sciences
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Depositing User: Natasha Hill
Date Deposited: 15 Jun 2017 15:15
Last Modified: 15 Jun 2017 15:15
URI: http://eprints.kingston.ac.uk/id/eprint/38355

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