Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers.

Khelwatty, Said A., Essapen, Sharadah, Seddon, Alan M., Fan, Zhen and Modjtahedi, Helmout (2015) Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers. British Journal of Cancer, 113(7), pp. 1010-1019. ISSN (print) 0007-0920

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Abstract

Our results provide a novel mechanistic insight into the development of acquired resistance to EGFR antibody-based therapy in colorectal cancer cells and justify further investigations on the therapeutic benefits of pan-HER family inhibitors in the treatment of colorectal cancer patients once acquired resistance to EGFR antibody-based therapy is developed.

Item Type: Article
Additional Information: This work was supported by a grant from Better Research Into Gastrointestinal Cancer Health and Treatment (BRIGHT), UK.
Research Area: Cancer studies
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing
Faculty of Science, Engineering and Computing > School of Life Sciences
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Depositing User: Automatic Import Agent
Date Deposited: 21 Sep 2015 19:30
Last Modified: 05 Feb 2016 09:12
URI: http://eprints.kingston.ac.uk/id/eprint/32508

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