Age-related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens

Abdelkader, H., Alany, R.G. and Pierscionek, B. (2015) Age-related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens. Journal of Pharmacy and Pharmacology, 67(4), pp. 537-550. ISSN (print) 0022-3573

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Abstract

This review discusses the anatomy and physiology of the lens and the changes that are understood to occur with ageing and cataract formation to identify potential areas for effective therapeutic intervention. Experimental techniques and agents used to induce cataract in animal models, the advantages and disadvantages of potential pharmacological treatments specific barriers to delivery of exogenous antioxidants to the lens and the prospects for future research are discussed.

Item Type: Article
Additional Information: This work was supported by the Leverhulme Trust; Research Fellowship Grant 2012
Uncontrolled Keywords: antioxidants, aspirin, bendazac and naltrexone, carnosine, carotenoids, cataract, crystallins, flavonoids, ocular delivery
Research Area: Pharmacy
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing
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Depositing User: Davina Omar
Date Deposited: 06 Nov 2014 14:07
Last Modified: 22 May 2015 08:08
URI: http://eprints.kingston.ac.uk/id/eprint/29385

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