Fibroblast Growth Factor 22 is not essential for skin development and repair but plays a role in tumorigenesis

Jarosz, Monika, Robbez-Masson, Luisa, Chioni, Athina-Myrto, Cross, Barbara, Rosewell, Ian and Grose, Richard (2012) Fibroblast Growth Factor 22 is not essential for skin development and repair but plays a role in tumorigenesis. PLoS ONE, 7(6), e39436. ISSN (online) 1932-6203

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Abstract

Fibroblast Growth Factors play critical roles during development, tissue homeostasis and repair by controlling cell proliferation, survival, migration and differentiation. Of the 22 mammalian FGFs, FGF22, a member of the FGF7/10/22 subfamily, has been shown to have a clear role in synaptogenesis, but its roles in other tissues have not been studied. We have investigated the in vivo functions of FGF22 in mice. Fgf22 null animals were viable, fertile and did not display any obvious abnormalities. Despite the known expression profile of FGF22 in the skin, no differences in either skin or pelage were observed, demonstrating that FGF22 is dispensable during embryogenesis and in unchallenged adult skin. Mice lacking FGF22 were able to heal acute wounds just as efficiently as wild type mice. However, classical two-step skin carcinogenesis challenge revealed that FGF22 null mice developed fewer papillomas than wild type controls, suggesting a potential pro-oncogenic role for FGF22 in the skin.

Item Type: Article
Additional Information: This work was supported by Cancer Research UK, the Wellcome Trust (076678/Z/05/Z) and the Trustees of St Barts and the London Charitable Foundation.
Research Area: Cancer studies
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing > School of Life Sciences
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Depositing User: Susan Miles
Date Deposited: 29 Sep 2014 15:03
Last Modified: 29 Sep 2014 15:03
URI: http://eprints.kingston.ac.uk/id/eprint/29185

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