The ins and outs of fibroblast growth factor receptor signalling

Coleman, Stacey J., Bruce, Charo, Chioni, Athina‑Myrto, Kocher, Hemant M. and Grose, Richard P. (2014) The ins and outs of fibroblast growth factor receptor signalling. Clinical Science, 127(4), pp. 217-231. ISSN (print) 0143-5221

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Abstract

FGFR (fibroblast growth factor receptor) signalling plays critical roles in embryogensis, adult physiology, tissue repair and many pathologies. Of particular interest over recent years, it has been implicated in a wide range of cancers, and concerted efforts are underway to target different aspects of FGFR signalling networks. A major focus has been identifying the canonical downstream signalling pathways in cancer cells, and these are now relatively well understood. In the present review, we focus on two distinct but emerging hot topics in FGF biology: its role in stromal cross-talk during cancer progression and the potential roles of FGFR signalling in the nucleus. These neglected areas are proving to be of great interest clinically and are intimately linked, at least in pancreatic cancer. The importance of the stroma in cancer is well accepted, both as a conduit/barrier for treatment and as a target in its own right. Nuclear receptors are less acknowledged as targets, largely due to historical scepticism as to their existence or importance. However, increasing evidence from across the receptor tyrosine kinase field is now strong enough to make the study of nuclear growth factor receptors a major area of interest.

Item Type: Article
Research Area: Cancer studies
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing > School of Life Sciences
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Depositing User: Susan Miles
Date Deposited: 29 Sep 2014 14:37
Last Modified: 29 Sep 2014 14:37
URI: http://eprints.kingston.ac.uk/id/eprint/29181

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