5.5 Successful insilico discovery of novel hypoxia regulated genes in pre-eclampsia.

Karanam, Vijaya, Anim-Nyame, Nick and Page, Nigel (2014) 5.5 Successful insilico discovery of novel hypoxia regulated genes in pre-eclampsia. In: Perinatal Medicine 2014; 9–11 June 2014, Harrogate, U.K.. ISSN (print) 1468-2052

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Abstract

DDD identified a total of 32 gene clusters to be differentially expressed and six of them were found to be hypoxia regulated. Angiogenin inhibitor, apolipoprotein E, NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 (NDUFAB1) and round about homolog 4 (ROBO4) were the upregulated genes and H19 and growth differentiating factor (GDF15) were the down regulated genes. Rt-QPCR studies showed similar results thus providing a proof that insilico techniques can be used as tools for novel gene discovery in gestational diseases like pre-eclampsia.

Item Type: Conference or Workshop Item (Speech)
Event Title: Perinatal Medicine 2014
Research Area: Allied health professions and studies
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing
Depositing User: Automatic Import Agent
Date Deposited: 30 Mar 2015 12:13
Last Modified: 30 Mar 2015 12:13
URI: http://eprints.kingston.ac.uk/id/eprint/28939

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