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'Campylobacter jejuni' gene cj0511 encodes a serine peptidase essential for colonisation

Karlyshev, A.V., Thacker, G., Jones, M.A., Clements, M.O. and Wren, B.W. (2014) 'Campylobacter jejuni' gene cj0511 encodes a serine peptidase essential for colonisation. FEBS Open Bio, 4, pp. 468-472. ISSN (online) 2211-5463

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Abstract

According to MEROPS peptidase database, Campylobacter species encode 64 predicted peptidases. However, proteolytic properties of only a few of these proteins have been confirmed experimentally. In this study we identified and characterised a Campylobacter jejuni gene cj0511 encoding a novel peptidase. The proteolytic activity associated with this enzyme was demonstrated in cell lysates. Moreover, enzymatic studies conducted with a purified protein confirmed a prediction of it being a serine peptidase. Furthermore, cj0511 mutant was found to be severely attenuated in chicken colonisation model, suggesting a role of the Cj0511 protein in infection.

Item Type: Article
Research Area: Allied health professions and studies
Biological sciences
Infection and immunology
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing
Faculty of Science, Engineering and Computing > School of Life Sciences
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Depositing User: Andrey Karlyshev
Date Deposited: 06 Jun 2014 09:09
Last Modified: 28 Aug 2014 18:05
URI: http://eprints.kingston.ac.uk/id/eprint/28472

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