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Maternal vitamin D status in pregnancy and offspring bone development: the unmet needs of vitamin D era

Karras, Spyridon N, Anagnostis, P, Bili, Helen, Naughton, Declan P., Petroczi, Andrea, Papadopoulou, Fotini and Goulis, Dimitrios G (2013) Maternal vitamin D status in pregnancy and offspring bone development: the unmet needs of vitamin D era. Osteoporosis International, ISSN (print) 0937-941X

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Abstract

Data from animal and human studies implicate maternal vitamin D deficiency during pregnancy as a significant risk factor for several adverse outcomes affecting maternal, fetal, and child health. The possible associations of maternal vitamin D status and offspring bone development comprise a significant public health issue. Evidence from randomized trials regarding maternal vitamin D supplementation for optimization of offspring bone mass is lacking. In the same field, data from observational studies suggest that vitamin D supplementation is not indicated. Conversely, supplementation studies provided evidence that vitamin D has beneficial effects on neonatal calcium homeostasis. Nevertheless, a series of issues, such as technical difficulties of current vitamin D assays and functional interplay among vitamin D analytes, prohibit arrival at safe conclusions. Future studies would benefit from adoption of a gold standard assay, which would unravel the functions of vitamin D analytes. This narrative review summarizes and discusses data from both observational and supplementation studies regarding maternal vitamin D status during pregnancy and offspring bone development.

Item Type: Article
Research Area: Allied health professions and studies
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing > School of Life Sciences
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Depositing User: Declan Naughton
Date Deposited: 14 Nov 2013 18:24
Last Modified: 30 May 2014 10:46
URI: http://eprints.kingston.ac.uk/id/eprint/26670

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