Three-dimensional visualization of dermal skin structure using confocal laser scanning microscopy

Antunes, A.P.M., Covington, A.D., Petford, N., Murray, T. and Wertheim, D. (2013) Three-dimensional visualization of dermal skin structure using confocal laser scanning microscopy. Journal Of Microscopy, 251(1), pp. 14-18. ISSN (print) 0022-2720

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Abstract

The properties and performance of collagen-based materials may be affected by the collagen fibre bundle pattern, orientation and weave. The aim of this study was to develop and apply methods to visualize the dermis using confocal laser scanning microscopy from thin tissue sections stained with haematoxylin and eosin. The data was processed to allow three-dimensional (3-D) visualization on a PC and using a 3-D immersive technology system. The 3-D visualization of the confocal microscope image stacks allowed the evaluation of the collagen macromolecular structure including the collagen fibre bundles. The methods developed provide a novel way of viewing complex organic structures with further potential applications in the medical field.

Item Type: Article
Additional Information: This work was supported by the European Regional Development Fund [EMX05527 - Modelling and Visualization].
Uncontrolled Keywords: Bovine, collagen, confocal laser scanning microscopy, dermis, H&E, immersive 3-D technology
Research Area: Computer science and informatics
Pre-clinical and human biological sciences
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing > School of Computing and Information Systems
Related URLs:
Depositing User: Maren Schroeder
Date Deposited: 05 Sep 2013 14:34
Last Modified: 05 Sep 2013 14:34
URI: http://eprints.kingston.ac.uk/id/eprint/26333

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