The influence of EDTMP-concentration on the biodistribution of radio-lanthanides and 225Ac in tumour-bearing mice

Beyer, G.J., Offord, R., Künzi, G., Aleksandrova, Yu., Ravn, U., Jahn, S., Barker, J., Tengblad, O., Lindroos, M. and ISOLDE Collaboration, . (1997) The influence of EDTMP-concentration on the biodistribution of radio-lanthanides and 225Ac in tumour-bearing mice. Nuclear Medicine and Biology, 24(5), pp. 367-372. ISSN (print) 0969-8051

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Abstract

High-resolution gamma spectroscopy was applied to measure simultaneously the biodistribution of carrier-free radionuclides of several lanthanides (141Ce, 145Sm, 149Gd, 167Tm) and 225Ac in tumor-bearing nude mice. Mixtures of the radiotracers were injected in solutions containing different concentrations of EDTMP (ethylenediaminetetramethylenephosphonic acid). The strong dependence of liver uptake on the ionic radius of the radio-lanthanides was confirmed for all tracers used. The ratios of radioactivity concentrated in tumour that concentrated in liver are strongly influenced by the EDTMP concentration, reaching values close to 10 for Tm, 3 for Sm, and 1 for Ac. The optimal EDTMP concentrations, giving highest tumor-to-liver ratios of enrichment, were between 1 and 10 mM for 100 microL injected volume for the animal model used in this experiment. In radionuclide therapy using EDTMP as ligands, close control of ligand concentration will be necessary.

Item Type: Article
Research Area: Pharmacy
Faculty, School or Research Centre: Faculty of Science (until 2011)
Depositing User: Kim Forbes
Date Deposited: 15 Aug 2008
Last Modified: 13 Jul 2016 10:22
URI: http://eprints.kingston.ac.uk/id/eprint/2460

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