Novel peptoids for the detection and suppression of reactive oxygen and nitrogen species

Fisher, A.E.O. and Naughton, D.P. (2003) Novel peptoids for the detection and suppression of reactive oxygen and nitrogen species. Biochemical Society Transactions, 31(6), pp. 1302-1304. ISSN (print) 0300-5127

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Abstract

Novel peptoids useful for the detection and suppression of various components contributing to oxidative stress and for elucidation of the interplay between these species are presented. Oxidative stress involves redox-active metal ion activation/generation of RONS (reactive oxygen and nitrogen species). For detection of RONS, the peptoid probes consist of a conjugate designed to (1) complex redox-active and non-redox-active metal ions, and (2) differentiate between RONS based upon the reaction products following RONS attack on the probe. For suppression of RONS, subtle modifications in peptoid structure impart catalase and superoxide dismutase activities to the peptoids upon ferric or cupric ion complexation.

Item Type: Article
Additional Information: This work was supported by the Engineering and Physical Sciences Research Council and the University of Brighton.
Research Area: Pharmacy
Faculty, School or Research Centre: Faculty of Science (until 2011)
Related URLs:
Depositing User: Declan Naughton
Date Deposited: 02 May 2008
Last Modified: 29 Feb 2012 11:42
URI: http://eprints.kingston.ac.uk/id/eprint/2374

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