Genomes and geography: genomic insights into the evolution and phylogeography of the genus 'Schistosoma'

Lawton, Scott P., Hirai, Hirohisa, Ironside, Joe E., Johnston, David A. and Rollinson, David (2011) Genomes and geography: genomic insights into the evolution and phylogeography of the genus 'Schistosoma'. Parasites & Vectors, 4(1), ISSN (online) 1756-3305

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Abstract

Blood flukes within the genus 'Schistosoma' still remain a major cause of disease in the tropics and subtropics and the study of their evolution has been an area of major debate and research. With the advent of modern molecular and genomic approaches deeper insights have been attained not only into the divergence and speciation of these worms, but also into the historic movement of these parasites from Asia into Africa, via migration and dispersal of definitive and snail intermediate hosts. This movement was subsequently followed by a radiation of Schistosoma species giving rise to the S. mansoni and S. haematobium groups, as well as the S. indicum group that reinvaded Asia. Each of these major evolutionary events has been marked by distinct changes in genomic structure evident in differences in mitochondrial gene order and nuclear chromosomal architecture between the species associated with Asia and Africa. Data from DNA sequencing, comparative molecular genomics and karyotyping are indicative of major constitutional genomic events which would have become fixed in the ancestral populations of these worms. Here we examine how modern genomic techniques may give a more in depth understanding of the evolution of schistosomes and highlight the complexity of speciation and divergence in this group.

Item Type: Article
Additional Information: Article ID: 131. This work is supported by the Natural Environment Research Council.
Research Area: Biological sciences
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing > School of Life Sciences
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Depositing User: Katrina Clifford
Date Deposited: 12 Apr 2012 10:36
Last Modified: 16 Jul 2012 21:55
URI: http://eprints.kingston.ac.uk/id/eprint/22058

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