Owen, C. G., Rudnicka, A. R., Nightingale, C. M., Mullen, R.., Barman, S. A., Sattar, N., Cook, D. G. and Whincup, P. H. (2011) Retinal arteriolar tortuosity and cardiovascular risk factors in a multi-ethnic population study of 10 year old children; the Child Heart And health Study in England (CHASE). Arteriosclerosis, Thrombosis, and Vascular Biology, 31(8), pp. 1933-1938. ISSN (print) 1079-5642Full text not available from this archive.
OBJECTIVE: To examine the association between cardiovascular risk factors and retinal arteriolar tortuosity in a multi-ethnic child population. METHODS AND RESULTS: Cross sectional study of 986 UK primary school children of South Asian, black African Caribbean, and white European origin aged 10 to 11 years. Anthropometric measurements and retinal imaging were carried out and a fasting blood sample collected. Digital images of retinal arterioles were analyzed using a validated semiautomated measure of tortuosity. Associations between tortuosity and cardiometabolic risk factors were analyzed using multi-level linear regression, adjusted for gender, age, ethnicity, arteriole branch status, month, and school. Levels of arteriolar tortuosity were similar in boys and girls and in different ethnic groups. Retinal arteriolar tortuosity was positively associated with levels of triglyceride, total and LDL cholesterol, and systolic and diastolic blood pressure. One standard deviation increases in these risk factors were associated with 3.7% (95% CI: 1.2%, 6.4%), 3.3% (0.9%, 5.8%), 3.1% (0.6%, 5.6%), 2.0% (-0.3%, 4.2%), and 2.3% (0.1%, 4.6%) increases in tortuosity, respectively. Adiposity, insulin resistance, and blood glucose showed no associations with tortuosity. CONCLUSIONS: Established cardiovascular risk factors, strongly linked to coronary heart disease in adulthood, may influence retinal arteriolar tortuosity at the end of the first decade of life.
|Uncontrolled Keywords:||epidemiology, risk factors, cardiovascular risk factors, childhood, retinal arteriolar tortuosity, blood-pressure, vessel tortuosity, vascular caliber, microvascular abnormalities, atherosclerosis risk, ethnic-differences, ocular biometry, disease, serum, mortality|
|Research Area:||Computer science and informatics
Health services research
|Faculty, School or Research Centre:||Faculty of Science, Engineering and Computing > Digital Imaging Research Centre (DIRC)|
|Depositing User:||Automatic Import Agent|
|Date Deposited:||22 Jul 2011 15:28|
|Last Modified:||16 Nov 2011 16:37|
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