A comparative evaluation of the metabolic profiles of normal and inflammatory knee-joint synovial fluids by high resolution proton NMR spectroscopy

Naughton, Declan P., Haywood, Rachel, Blake , David R., Edwards, Sally, Hawkes, Geoffrey and Grootveld, Martin (1993) A comparative evaluation of the metabolic profiles of normal and inflammatory knee-joint synovial fluids by high resolution proton NMR spectroscopy. FEBS Letters, 332(3), pp. 221-225. ISSN (print) 0014-5793

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Abstract

High resolution 1H NMR spectroscopy has been employed to investigate the metabolic profile of healthy human knee-joint synovial fluid (SF) and the biochemical data acquired have been compared with those of matched serum, and inflammatory knee-joint SF samples. Results obtained indicate that the healthy human knee-joint has a hypoxic status (high lactate level when expressed relative to that of paired serum) that is milder than that of the inflamed human knee-joint. Moreover, normal SF differs from that of inflammatory SF in that it contains little or no NMR-detectable lipoprotein-associated fatty acids and 'acute-phase' glycoproteins, an observation reflecting the limited passage of these macromolecules from plasma into the synovial space in healthy subjects.

Item Type: Article
Additional Information: This work was supported by the Arthritis and Rheumatism Council (UK) [grant number B0141] and the Ministry of Agriculture, Fisheries and Food (UK).
Research Area: Allied health professions and studies
Faculty, School or Research Centre: Faculty of Science (until 2011) > School of Life Sciences
Related URLs:
Depositing User: Declan Naughton
Date Deposited: 28 Feb 2012 10:14
Last Modified: 28 Feb 2012 10:14
URI: http://eprints.kingston.ac.uk/id/eprint/18236

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