Naughton, Declan P., Haywood, Rachel, Blake, David R., Edwards, Sally, Hawkes, Geoffrey and Grootveld, Martin (1993) A comparative evaluation of the metabolic profiles of normal and inflammatory knee-joint synovial fluids by high resolution proton NMR spectroscopy. FEBS Letters, 332(3), pp. 221-225. ISSN (print) 0014-5793Full text not available from this archive.
High resolution 1H NMR spectroscopy has been employed to investigate the metabolic profile of healthy human knee-joint synovial fluid (SF) and the biochemical data acquired have been compared with those of matched serum, and inflammatory knee-joint SF samples. Results obtained indicate that the healthy human knee-joint has a hypoxic status (high lactate level when expressed relative to that of paired serum) that is milder than that of the inflamed human knee-joint. Moreover, normal SF differs from that of inflammatory SF in that it contains little or no NMR-detectable lipoprotein-associated fatty acids and 'acute-phase' glycoproteins, an observation reflecting the limited passage of these macromolecules from plasma into the synovial space in healthy subjects.
|Additional Information:||This work was supported by the Arthritis and Rheumatism Council (UK) [grant number B0141] and the Ministry of Agriculture, Fisheries and Food (UK).|
|Research Area:||Allied health professions and studies|
|Faculty, School or Research Centre:||Faculty of Science (until 2011) > School of Life Sciences|
|Depositing User:||Declan Naughton|
|Date Deposited:||28 Feb 2012 10:14|
|Last Modified:||28 Feb 2012 10:14|
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