Effect of quadriceps strength and proprioception on risk for knee osteoarthritis

Segal, Neil A., Glass, Natalie A., Felson, David T., Hurley, Michael, Yang, Mei, Nevitt, Michael, Lewis, Cora E. and Torner, James C. (2010) Effect of quadriceps strength and proprioception on risk for knee osteoarthritis. Medicine and Science in Sports and Exercise, 42(11), pp. 2081-2088. ISSN (print) 0195-9131

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Abstract

PURPOSE: Impaired quadriceps strength and joint position sense (JPS) have been linked with knee osteoarthritis (OA) cross-sectionally. Although neither has been independently associated with incident radiographic OA, their combination may mediate risk. The purpose of this study was to determine whether better sensorimotor function protects against the development of incident radiographic or symptomatic knee OA. METHODS: The Multicenter Osteoarthritis study is a longitudinal study of adults aged 50–79 yr at high risk for knee OA. Participants underwent bilateral, weight-bearing, fixed-flexion radiographs, JPS acuity tests, and isokinetic quadriceps strength tests. The relationships between combinations of the tertiles of sex-specific baseline peak strength and mean JPS and development of incident radiographic (Kellgren–Lawrence (KL) grade Q2) or symptomatic knee OA (KL grade Q2 and frequent knee pain or stiffness) at a 30-month follow-up were evaluated. Secondary analyses defined JPS as the variance during the 10 JPS trials and also assessed the interaction of strength and JPS in predicting each outcome. RESULTS: The study of incident radiographic knee OA included 1390 participants (age = 61.2 ± 7 .9 yr and body mass index = 29.4 ± 5.1 kg·m−²), and the study of incident symptomatic knee OA included 1829 participants (age = 62.2 ± 8.0 yr and body mass index = 30.0 ± 5.4 kg·m−²). Greater strength at baseline protected against incident symptomatic but not radiographic knee OA regardless of JPS tertile. There was no significant relationship between the strength–JPS interaction and the development of radiographic or symptomatic knee OA. CONCLUSIONS: The finding that quadriceps strength protected against incident symptomatic but not radiographic knee OA regardless of JPS tertile suggests that strength may be more important than JPS in mediating risk for knee OA.

Item Type: Article
Additional Information: This work was supported by the National Institutes of Health [grant numbers AG18820, AG18832, AG18947, AG19069] and Beeson Career Development Award [grant number K23AG030945].
Research Area: Allied health professions and studies
Health services research
Faculty, School or Research Centre: Faculty of Health and Social Care Sciences (until 2013)
Related URLs:
Depositing User: Gemma Sansom
Date Deposited: 18 Jan 2011 08:54
Last Modified: 03 Mar 2014 13:39
URI: http://eprints.kingston.ac.uk/id/eprint/17958

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