TIS11 family proteins and their roles in posttranscriptional gene regulation

Baou, Maria, Jewell, Andrew and Murphy, John J. (2009) TIS11 family proteins and their roles in posttranscriptional gene regulation. Journal of Biomedicine and Biotechnology, 2009, ISSN (print) 1110-7243

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Abstract

Posttranscriptional regulation of gene expression of mRNAs containing adenine-uridine rich elements (AREs) in their 3' untranslated regions is mediated by a number of different proteins that interact with these elements to either stabilise or destabilise them. The present review concerns the TPA-inducible sequence 11 (TIS11) protein family, a small family of proteins, that appears to interact with ARE-containing mRNAs and promote their degradation. This family of proteins has been extensively studied in the past decade. Studies have focussed on determining their biochemical functions, identifying their target mRNAs, and determining their roles in cell functions and diseases.

Item Type: Article
Additional Information: No page numbers. Article ID: 634520.
Research Area: Biological sciences
Health services research
Faculty, School or Research Centre: Faculty of Health and Social Care Sciences (until 2013)
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Depositing User: Gemma Sansom
Date Deposited: 28 Jun 2010 08:27
Last Modified: 16 Jul 2012 21:49
URI: http://eprints.kingston.ac.uk/id/eprint/15406

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