Scope of the Heck reaction in the synthesis of of a new family of anthracene diacrylamide G-quadruplex ligands

Le Gresley, Adam, Abdullah, Ammara, Desai, Prachi, Ghosh, Uttam, Gollapalli, Uma, Kiran, Munazza and Lafona, Shehri (2010) Scope of the Heck reaction in the synthesis of of a new family of anthracene diacrylamide G-quadruplex ligands. Synthetic Communications, 41(16), pp. 2483-2492. ISSN (print) 0039-7911

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Abstract

The use of the Heck reaction in the synthesis of anthracene-9-monoacrylamide and anthracen-9,10-bisacrylamides as potential G-quadruplex ligands and preliminary biological testing is reported.

Item Type: Article
Uncontrolled Keywords: acrylamide, anthracene, g-quadruplex, heck, dynamic combinatorial chemistry, telomerase inhibition, small-molecule, DNA, libraries, assay
Research Area: Chemistry
Faculty, School or Research Centre: Faculty of Science (until 2011) > School of Pharmacy and Chemistry
Faculty of Science (until 2011)
Depositing User: Adam Le Gresley
Date Deposited: 14 Jan 2013 10:04
Last Modified: 14 Jan 2013 10:04
URI: http://eprints.kingston.ac.uk/id/eprint/15203

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