Why inverse proteins are relatively abundant

Nebel, Jean-Christophe and Walawage, Claude Godfrey Charles (2010) Why inverse proteins are relatively abundant. Protein and peptide letters, 17(7), pp. 854-860. ISSN (print) 0929-8665

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Abstract

Studies have shown that inverse proteins are relatively abundant. In this work, we investigate the proposition that the repeat patterns they share with protein sequences explain this phenomenon. Using a new artificial set of peptide sequences which also display these features and a random set, we show that the presence of repeats contributes to protein sequence similarity. Further analysis confirms that most inverse proteins exhibit repeats. Therefore, we suggest the relative abundance of inverse proteins can be explained by the fact they display the same repeat structures and amino acid propensity of existing proteins.

Item Type: Article
Uncontrolled Keywords: amino acid propensity, inverse proteins, nullomers, random peptide chains, repeats, sequence similarity, data-bank, prediction, evolution, repeats
Research Area: Chemistry
Biological sciences
Faculty, School or Research Centre: Faculty of Computing, Information Systems and Mathematics (until 2011)
Faculty of Computing, Information Systems and Mathematics (until 2011) > Digital Imaging Research Centre (DIRC)
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Depositing User: Automatic Import Agent
Date Deposited: 01 Jun 2010 08:43
Last Modified: 26 Jul 2012 11:43
URI: http://eprints.kingston.ac.uk/id/eprint/12120

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